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KMID : 0191120110260020207
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Journal of Korean Medical Science
2011 Volume.26 No. 2 p.207 ~ p.213
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DNA Methylation Changes Following 5-azacitidine Treatment in Patients with Myelodysplastic Syndrome
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Tran Huong Thi Thanh
Kim Hee-Nam
Lee Il-Kwon
Kim Yeo-Kyeoung
Ahn Jae-Sook
Yang Deok-Hwan
Lee Je-Jung
Kim Hyeoung-Joon
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Abstract
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DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation of CDKN2B,FHIT,ESR1, and IGSF4 gene was detected in 9/44 patients. In concordance with the clinical response, a lack of or decreased methylation in 4 patients with hematologic improvements and persistent methylation in 4 others with no response was observed. The mRNA expression of CDKN2B,IGSF4, and ESR1 was significantly reduced in MDS. Our results suggest that methylation changes contribute to disease pathogenesis and may serve as marker to monitor the efficacy of treatments.
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KEYWORD
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Demethylation, DNA Methylation, Myelodysplastic Syndromes, DNA Methyltransferase Inhibitors, Azacitidine, MS-MLPA
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